Rapamycin-loaded polysorbate 80-coated PLGA NPs Examples of drugs/bioactive ingredients loaded in polymeric nanoparticles are depicted in Table 1.Ĭ-6-loaded polymeric core-shell NPs (polymeric core-multilayer polyelectrolyte shell NPs), obtained by prepared by the spontaneous emulsification solvent evaporation methodĭrug delivery, theranostics, or bioimaging These two types of polymeric NPs recognized as a reservoir system (nanocapsule), and matrix system (nanosphere) are shown in Figure 1. Nanospheres are based on a continuous polymeric network in which the drug can be retained inside or adsorbed onto their surface. Nanocapsules are composed of an oily core in which the drug is usually dissolved, surrounded by a polymeric shell which controls the release profile of the drug from the core. The term “nanoparticle” comprises both nanocapsules and nanospheres, which differ with respect to their morphology. Advantages of polymeric NPs as drug carriers include their potential use for controlled release, the ability to protect drug and other molecules with biological activity against the environment, improve their bioavailability and therapeutic index. Polymeric nanoparticles (NPs) have attracted considerable interest over recent years due to their properties resulting from their small size.
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